A team at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC - CNRS/Université de Strasbourg/Inserm) has evidenced, at the atomic scale, the three-dimensional structure of the complete human ribosome and the detailed interactions that occur within it. These findings, obtained using a technology that is unique in France, open the way to further exploring some of the adverse effects of antibiotics, and, in the longer term, to the treatment of diseases related to ribosomal dysfunctions and the deregulation of protein synthesis. This work is published in Nature on 22 April 2015.
To download the press release:
Structure of the human 80S ribosome ; H. Khatter, A.G. Myasnikov, S. K. Natchiar & B.P. Klaholz ; Nature ; 22 April 2015.