The Lancet, Volume 376, Issue 9741
, Pages 568 - 570, 21 August 2010
doi:10.1016/S0140-6736(10)60896-3Cite or Link Using DOI
This article can be found in the following collection: Public Health
Copyright © 2010 Elsevier Ltd All rights reserved.
Rotavirus: realising the potential of a promising vaccine
In 2006, two studies that described the efficacy and safety of two new oral rotavirus vaccines were joint winners of The Lancet's
Paper of the Year. 1—3
These trials had been done in infants in high-income and middle-income countries in the Americas and Europe, but no efficacy data were available for infants in low-income populations in Africa and Asia where 85% of the more than 500 000 deaths from rotavirus occur. 4
Unlike parenteral vaccines, live oral vaccines have behaved differently in high-incom ...
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a Department of Paediatrics, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China b Fogarty International Center, National Institutes of Health, Bethesda, MD, USA