Liver disease is reported to be the third largest cause of premature death in the UK, with 75% of patients being diagnosed too late for any meaningful intervention. Dr Matthew Hoare from the University of Cambridge, and Dr Peter Campbell from the Sanger Institute, lead a team conducting research into the genome changes associated with chronic liver disease to help understand the cause and consequence of these changes.
Following exposure to injury or infection, the body elicits a counteractive immune response which involves many different cell types and processes. Cytokines are substances secreted by cells which play a pivotal role in the regulation of this response. Professor Paige Lacy and colleagues in the Department of Medicine at the University of Alberta in Edmonton, Canada, have conducted extensive research into the exact mechanisms underpinning the regulation of cytokine release during the immune response with a particular focus on airway inflammatory disorders.
Dr Ilida Ortega Asencio | Template-driven Electrospinning: A Smart Manufacturing Approach to Treating Skin Injuries
Human skin acts as an important line of defence against the external environment. To preserve this important function, the regeneration of injured skin is critical. Scientists are now able to artificially replicate aspects of the complex microenvironment in which human skin stem cells reside thanks to the technological advances in the field of biomaterial devices. Dr Ilida Ortega Asencio, from the University of Sheffield, UK, and her team have developed a new approach in which electrospun patches with defined microenvironments can be functionalised with key compounds to aid the formation of new blood vessels in injured skin.
Chemotherapy, one of the mainstays of cancer treatment, can unfortunately act as a double-edged sword. While achieving the intended aim of killing cancerous cells, it also generates an accumulation of cell debris, which in turn, promotes tumour growth by stimulating inflammation in the tumour microenvironment. Dr Dipak Panigrahy and his colleagues from Harvard Medical School, USA, have conducted several studies in mice showing that targeting the tumour cell debris-mediated surge of proinflammatory and protumourigenic factors provides a strategy for enhancing the efficacy of chemotherapy.
Children and youth who experience trauma often develop posttraumatic stress symptoms, and some go on to develop posttraumatic stress disorder or PTSD. Toria Herd from the Pennsylvania State University, US, is exploring the factors that put adolescents at risk of developing PTSD and also those that may protect against this consequence associated with trauma exposure. Her findings have important implications for the trauma-informed care of young people and the reduction of the long-term impact of trauma on individuals and families.
Professor Manoj Sharma | The Multi-theory Model (MTM) of Health Behavior Change: Understanding the Determinants of Breast Cancer Screening
The multi-theory model (MTM) of health behavior change provides a theoretical framework for understanding and promoting health behaviors. Professor Manoj Sharma from the University of Nevada, Las Vegas, the originator of this model, has applied this model to breast cancer and undertaking mammography screening in women from groups underserved in current healthcare. His findings have important theoretical and practical implications.