1. When a metabolic substrate or drug diffuses from the bloodstream into the tissue, a. the mass leaving the blood per minute is called the extraction. b. the fraction of the substance removed per minute is called the clearance. c. the quantity removed per minute equals the blood flow arterio-venous concentration difference. d. the quantity removed per minute is given by the Fick principle. e. the mean capillary concentration of a drug is 6 mM if the arterial concentration is 8 mM and local venous concentration is 4 mM.
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