Nuclear factor-erythroid-2-related factor 2 (Nrf2) is a binding protein that plays a significant role in the antioxidant response of the body. It is the primary cellular defense against the cytotoxic effects of oxidative stress. This key protein rests inside the cell and is unable to move or operate until it is released by an Nrf2 activator. Once released it migrates into the cell nucleus and bonds to the DNA at the location of the Antioxidant Response Element (ARE), the master regulator of the total antioxidant system available within each cell. Studies suggest that Nrf2 plays an important role in supporting the activation of cellular antioxidant systems as well as inflammatory balance. A number of fruit and vegetable compounds have been shown to increase Nrf2. It is believed that these compounds have a protective effect on the body, maintain a healthy cycle of inflammation, and induce cellular longevity.
Resvoxitrol is a unique combination of phytonutrients designed to enhance antioxidant potential by stimulating Nrf2. This exclusive blend of pterostilbene, resveratrol, broccoli seed extract, pomegranate and alpha lipoic acid has a wide array of biological activity including direct free radical scavenging potential as well as inducing intracellular antioxidant production. These potent phytochemicals are the basis of many “superfoods” and have extensive, peer-reviewed research supporting their dramatic effect on cell health and longevity.
2 capsules per day or as recommended by your health care professional
Plants have compounds called phytochemicals that have numerous health benefits. One of these compounds, called Stilbenes, is a sub-group of phytochemicals called polyphenols with potent antioxidant properties. They are produced when the plant is exposed to an environmental threat such as viral, microbial or ultraviolet exposure and protect the plants from such threats. Pterostilbene is a specific stilbene found in such plant varieties as deerberry, rabbiteye blueberries, unripe Pinot noir and Botrytis vinifera infected Chardonnay grapes, and Xarello grapes
Resveratrol, like pterostilbene, is a stilbene found in many plants and red wines. It is the most well-researched and known stilbene. Studies of resveratrol have found it to enhance the potential of antioxidant and detoxification activity, as well as positively influence healthy inflammation processes and longevity. Other studies have begun linking resveratrol to enhancing blood sugar balance and for its ability to improve cognitive health.
SGS™ Broccoli Seed Extract
SGS™ Broccoli Seed Extract contains the highest levels of glucoraphanin (a potent Nrf2 stimulator) of any broccoli product available. Glucoraphanin is a phytochemical compound that is the precursor to sulforaphane. Sulforaphane is the leading compound in broccoli and responsible for many of its positive benefits. These compounds and their mechanisms have been studied extensively and supported by more than 500 scientific publications. Sulforphane is a potent antioxidant shown to support detoxification, healthy inflammation balance and long-term health. Studies show sulforphane works by improving hormone balance and increasing functional enzymes that support excretion of toxins from the body. The activity of SGS™ Broccoli Seed Extract has been shown to remain active within the body for up to three days following consumption.
Quercetin is a bioflavonoid found in high concentrations in onions, garlic, horseradish and other fruits and vegetables. Quercetin has been shown to enhance antioxidant activity, regulate inflammatory balance and support strong cardiovascular function.
The pomegranate is a phytochemical-rich fruit that contains ellagic acid, punicalagins, anthocyanidins and flavonoids – all compounds shown to increase plasma antioxidant levels. The Pomegranate 40P used in Resvoxitrol is an extract of the whole fruit excluding the juice. The whole fruit is squeezed to remove the juice and the extract is made from the remaining pulp, seeds, and skin. This extract is standardized to contain no less than 40% punicosides. Pomegranate 40P supports antioxidant activity, healthy microbial activity, and inflammatory balance. Recent studies have also shown supplementing pomegranate enhances cardiovascular function when consumed regularly.
Alpha Lipoic Acid
Alpha-lipoic acid is an antioxidant that is made by the body and is found in every cell, where it helps turn glucose into energy. It is a potent antioxidant capable of restoring other antioxidants including vitamin C, vitamin E and glutathione. Studies show that lipoic acid scavenges free radicals, supporting optimal antioxidant activity and healthy inflammation balance. In some studies alpha lipoic acid has been shown to support nerve function and improve cognitive health.