What Is Biochemistry - Biotin Deficiency
Biotin deficiency may present with symptoms and signs such as gastrointestinal upset, dermatitis, alopecia, paraesthesia and muscle ache.
Biotin involved in gluconeogenesis ( conversion of pyruvate to oxaloacetate ) by acting as a cofactor to the pyruvate carboxylase.
Biotin also involved in the synthesis of fatty acid by converting acetyl CoA into malonyl CoA by acting as cofactor to acetyl CoA carboxylase.
Biotin is associated also with fatty acid metabolism by breaking down propionyl CoA into methylmalonyl CoA. Biotin will act as cofactor to propionyl CoA carboxylase.
Generally biotin will be taken from diet or synthesized by intestinal flora which present in the bowel.
Biotin deficiency may occur due to long term of parenteral nutrition or increase intake of raw egg whites. Raw egg whites consists of avidin. Avidin will interfere with digestion of biotin.
Long term antibiotic intake may also lead to deficiency of biotin.
Laboratory investigation may reveal raise in cholesterol level in biotin deficiency patient.
Patient may require supplement of biotin in cases of long term intake of antibiotic or parenteral nutrition.