Contents. List of Contributors. Preface (E.E. Bittar and N. Bittar). Proteins: An Introduction (N.M. Allewell, V.J. Licata, and Xiaoling Yuan). How Enzymes Work (G.L. Nelsestuen). Substrate Utilization in Mammalian Cells (G.J. van der Vusse and R.S. Reneman). The Organization of Metabolic Pathways In Vivo (G.R. Welch). Enzyme Kinetics In Vitro and In Vivo: Michaelis-Menten Revisited (M.A. Savageau). The Basis of Enzymatic Adaptation (K.B. Storey and S.P.J. Brooks). Our Aquesous Heritage: Evidence for Vicinal Water in Cells (W. Drost-Hansen and J.L. Singleton). Our Aqueous Heritage: Role of Vicinal Water in Cells (W. Drost-Hansen and J.L. Singleton). Intracellular Water and the Regulation of Cell Volume and pH (H.G. Hempling). Protein Synthesis and Regulation in Eukaryotes (S.I.S. Rattan). The Role of Glycosylation in Cell Regulation (E.F. Hounsell). Why are Proteins Methylated? (S. Clarke). ADP-ribosylation Reactions (C.K. Pearson). Modification of Proteins by Prenyl Groups (M.H. Gelb). Lipobiology (D.A. Ford and R.W. Gross). Index.