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Oct 16

cuSBF: A Minimizer-Aware Bloom Filter for Genomic Sequence Data on Modern GPUs

Efficient genomic k-mer indexing depends on approximate membership query (AMQ) structures that must deliver high throughput, low false-positive rates (FPR), and modest memory footprints. The Super Bloom filter (SBF) is attractive for this scenario because minimizer-guided sharding and the Findere scheme exploit the redundancy of overlapping k-mers. However, those same features cause high per-k-mer compute cost, severe register pressure, and irregular memory accesses, which hinder an effective GPU implementation. We present cuSBF, an open-source, header-only CUDA library that implements SBF for sequence-native workloads. cuSBF's design merges sectorized shards, cooperative shared-memory tiling, warp-level shard sharing, and segmented warp reductions, turning super-k-mer locality into scalable GPU parallelism. Across real genomic workloads on RTX PRO 6000 Blackwell and GH200 systems, cuSBF achieves the highest throughput among all evaluated sequence-capable baselines. On the RTX PRO 6000, it surpasses the cuCollections blocked Bloom filter baseline by up to 9.1x for insertion and 7.7x for query, while reaching up to 92x and 234x speedups over the multi-threaded CPU Super Bloom reference implementation. It also outperforms GPU-based dynamic AMQs (Cuckoo, Two-Choice, Quotient filters) by 1.5-3400x depending on workload characteristics. A parameter sweep identifies (s = 28, m = 16, H = 4) as Pareto-optimal for k = 31, yielding significantly lower FPR than cuCollections at matched memory budgets. Crucially, cuSBF's architecture-aware design sustains 85% streaming multiprocessor utilization even for out-of-cache filters - proving that sequence locality, not raw bandwidth, is the key to GPU-accelerated genomic indexing.

  • 3 authors
·
Jun 22

Planning In Natural Language Improves LLM Search For Code Generation

While scaling training compute has led to remarkable improvements in large language models (LLMs), scaling inference compute has not yet yielded analogous gains. We hypothesize that a core missing component is a lack of diverse LLM outputs, leading to inefficient search due to models repeatedly sampling highly similar, yet incorrect generations. We empirically demonstrate that this lack of diversity can be mitigated by searching over candidate plans for solving a problem in natural language. Based on this insight, we propose PLANSEARCH, a novel search algorithm which shows strong results across HumanEval+, MBPP+, and LiveCodeBench (a contamination-free benchmark for competitive coding). PLANSEARCH generates a diverse set of observations about the problem and then uses these observations to construct plans for solving the problem. By searching over plans in natural language rather than directly over code solutions, PLANSEARCH explores a significantly more diverse range of potential solutions compared to baseline search methods. Using PLANSEARCH on top of Claude 3.5 Sonnet achieves a state-of-the-art pass@200 of 77.0% on LiveCodeBench, outperforming both the best score achieved without search (pass@1 = 41.4%) and using standard repeated sampling (pass@200 = 60.6%). Finally, we show that, across all models, search algorithms, and benchmarks analyzed, we can accurately predict performance gains due to search as a direct function of the diversity over generated ideas.

  • 10 authors
·
Sep 5, 2024 1

On-shell renormalization of sine-Gordon by the quantum inverse scattering method

In the quantum inverse scattering method, the sine-Gordon model is solved on a lattice, and its continuum and infinite-volume limits become uniform only after the length of the box is rescaled. We show that this rescaling, supplemented by an on-shell condition, defines a renormalization scheme. The whole dependence on the cut-off is absorbed into a factor Z_L multiplying the length of the box, with an exponent fixed by the scaling dimension of the vertex operator; neither the field nor the coupling β is renormalized, no subtraction scale is introduced, and the mass parameter receives a finite renormalization, fixed by requiring that the lightest breather has the mass of the boson in the linearized theory. The soliton and breather masses follow from the eigenvalues of the monodromy operator as functions of parameters that do not run, and reduce to the classical and semiclassical results as βrightarrow0. In particular, the mass ratios are produced directly from the regularized construction, while the relation between the lattice parameters and the physical scale is absorbed into Z_L and never needs to be computed. The scheme is a reparameterization of the theory which makes explicit the interplay between integrability and renormalization. We compare it with Coleman's normal ordering and with conformal perturbation theory, and we argue that it extends to ultralocal integrable theories with a massive spectrum, possibly including asymptotically free models that admit an ultralocal lattice regularization.

  • 2 authors
·
Sep 30